Platelet Reactivity and Outcomes after Off-Pump Coronary Surgery in Acute Coronary Syndrome Patients.

ABSTRACT: Ischemic and hemorrhagic complications are major determinants of survival in acute coronary syndrome (ACS) patients undergoing coronary surgery. We investigated the association of preoperative platelet reactivity to P2Y₁₂ antagonists with ischemic and hemorrhagic complications after Off-Pump Coronary Artery Bypass surgery (OPCAB) in ACS patients who received dual anti-platelet therapy (DAPT) within 5 days prior to surgery. This prospective, observational study with 177 patients compared the incidence of perioperative major bleeding and major adverse cardiac events (MACEs) in relation to the tertile distribution of the % inhibitory response to P2Y₁₂ antagonists, as measured by a thromboelastography platelet mapping assay. The incidences of perioperative major bleeding

SUBMITTER: Soh S 

PROVIDER: S-EPMC9224657 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature