Precision Medicine in Head and Neck Cancers: Genomic and Preclinical Approaches.

ABSTRACT: Head and neck cancers (HNCs) represent the sixth most widespread malignancy worldwide. Surgery, radiotherapy, chemotherapeutic and immunotherapeutic drugs represent the main clinical approaches for HNC patients. Moreover, HNCs are characterised by an elevated mutational load; however, specific genetic mutations or biomarkers have not yet been found. In this scenario, personalised medicine is showing its efficacy. To study the reliability and the effects of personalised treatments, preclinical research can take advantage of next-generation sequencing and innovative technologies that have been developed to obtain genomic and multi-omic profiles to drive personalised treatments. The crosstalk between malignant and healthy components, as well as interactions with extracellular matrices, are im

SUBMITTER: Miserocchi G 

PROVIDER: S-EPMC9224778 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature