Pharmacogenomic Profile of Amazonian Amerindians.

ABSTRACT: Given the role of pharmacogenomics in the large variability observed in drug efficacy/safety, an assessment about the pharmacogenomic profile of patients prior to drug prescription or dose adjustment is paramount to improve adherence to treatment and prevent adverse drug reaction events. A population commonly underrepresented in pharmacogenomic studies is the Native American populations, which have a unique genetic profile due to a long process of geographic isolation and other genetic and evolutionary processes. Here, we describe the pharmacogenetic variability of Native American populations regarding 160 pharmacogenes involved in absorption, distribution, metabolism, and excretion processes and biological pathways of different therapies. Data were obtained through complete exome sequenci

SUBMITTER: Rodrigues JCG 

PROVIDER: S-EPMC9224798 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature