Thermally Induced Transitions of d(G₄T₄G₃) Quadruplexes Can Be Described as Kinetically Driven Processes.

ABSTRACT: DNA sequences that are rich in guanines and can form four-stranded structures are called G-quadruplexes. Due to the growing evidence that they may play an important role in several key biological processes, the G-quadruplexes have captured the interest of several researchers. G-quadruplexes may form in the presence of different metal cations as polymorphic structures formed in kinetically governed processes. Here we investigate a complex polymorphism of d(G₄T₄G₃) quadruplexes at different K⁺ concentrations. We show that population size of different d(G₄T₄G₃) quadruplex conformations can be manipulated by cooling rate and/or K⁺ concentration. We use a kinetic model to describe data obtained from DSC, CD

SUBMITTER: Prislan I 

PROVIDER: S-EPMC9225023 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature