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Comment on Ceruti et al. Temporal Changes in the Oxyhemoglobin Dissociation Curve of Critically Ill COVID-19 Patients. J. Clin. Med. 2022, 11, 788.

ABSTRACT: Ceruti et al. describe in their article very low standard half saturation pressures (P50) in COVID-19 patients, calculated with the Dash et al. equations. By using the Hill equation and Severinghaus' coefficients we obtained normal values. The authors who do not present a pathophysiological cause for their results should explain this discrepancy. Independent of the absolute values a continuous moderate decrease of P50 in the surviving patients might be of clinical importance.

SUBMITTER: Boning D 

PROVIDER: S-EPMC9225162 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Comment on Ceruti et al. Temporal Changes in the Oxyhemoglobin Dissociation Curve of Critically Ill COVID-19 Patients. <i>J. Clin. Med.</i> 2022, <i>11</i>, 788.

Böning Dieter D   Bloch Wilhelm W   Kuebler Wolfgang M WM  

Journal of clinical medicine 20220613 12

Ceruti et al. describe in their article very low standard half saturation pressures (P<sub>50</sub>) in COVID-19 patients, calculated with the Dash et al. equations. By using the Hill equation and Severinghaus' coefficients we obtained normal values. The authors who do not present a pathophysiological cause for their results should explain this discrepancy. Independent of the absolute values a continuous moderate decrease of P<sub>50</sub> in the surviving patients might be of clinical importanc  ...[more]

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