Vulvovaginal Candida albicans Clinical Isolates' Resistance to Phagocytosis In-Vitro.

ABSTRACT: Previous studies have revealed that Candida albicans isolates involved in chronic vulvovaginal candidosis (cVVC) phenotypically express less virulent traits than clinical isolates involved in sporadic infections. In this study, we aimed to further explore this finding by studying the behaviour of those same clinical isolates in in-vitro models of infection. Eighteen clinical Candida albicans isolates were collected from women suffering sporadic (eight isolates) or chronic infections (ten isolates). Adhesion to HeLa cells (human cervical cancer epithelial cell line) and resistance to phagocytosis by RAW 264.7 cells (murine macrophages cell line) were tested in-vitro. In addition, phenotypic expression of virulence factors related with either adhesion or resistance to phagocyto

SUBMITTER: Faria-Goncalves P 

PROVIDER: S-EPMC9225182 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature