Biomarkers of caspofungin resistance in Candida albicans isolates: A proteomic approach.

ABSTRACT: Candida albicans is a clinically important polymorphic fungal pathogen that causes life-threatening invasive infections in immunocompromised patients. Antifungal therapy failure is a substantial clinical problem, due to the emergence of an increasing number of drug-resistant isolates. Caspofungin is a common antifungal drug, often used as first-line therapy that inhibits cell wall β-(1,3)-glucan synthesis. In this work, the cell surface of different echinocandin-resistant C. albicans clinical isolates was compared with sensitive isolates and their responses to echinocandin treatment analyzed. Proteomic analysis detected changes in the repertoire of proteins involved in cell wall organization and maintenance, in drug-resistant strains compared to susceptible isolates and after

SUBMITTER: De Cesare GB 

PROVIDER: S-EPMC9225221 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature