Autophagy-dependent glutaminolysis drives superior IL21 production in HIV-1-specific CD4 T cells.

ABSTRACT: The maintenance of a strong IL21 production in memory CD4 T cells, especially in HIV-1-specific cells, represents a major correlate of natural immune protection against the virus. However, the molecular mechanisms underlying IL21 production during HIV-1 infection, which is only elevated among the naturally protected elite controllers (EC), are still unknown. We recently found out that lipophagy is a critical immune mediator that control an antiviral metabolic state following CD8A T cell receptor engagement, playing an important role in the natural control of HIV-1 infection. This led us to investigate whether the beneficial role of a strong macroautophagy/autophagy, could also be used to ensure effective IL21 production as well. Herein, we confirm that after both polyclonal and HIV-1-speci

SUBMITTER: Loucif H 

PROVIDER: S-EPMC9225533 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature