TRIM24 Expression as an Independent Biomarker for Prognosis and Tumor Recurrence in HNSCC.

ABSTRACT:

Background

Head and neck squamous cell carcinomas (HNSCCs) are among the most common cancers in humans worldwide and have a rather poor prognosis. TRIM24 has various intracellular functions and was identified in other cancer entities as a poor prognostic factor for patients.

Methods

The expression of TRIM24 was evaluated by using immunohistochemistry. We used a large and representative cohort of 341 HNSCC patients. Data derived from immunohistochemistry evaluation was correlated with clinicopathological data from HNSCC patients.

Results

The TRIM24 expression in HNSCC primary tumors is negatively correlated with the p16 status of the tumor tissues. Primary tumors of patients who developed a local recurrence were significantly more often positive for TRIM24. Kaplan-Meie

SUBMITTER: Klapper L 

PROVIDER: S-EPMC9225579 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature