Cu²⁺ Release from Polylactic Acid Coating on Titanium Reduces Bone Implant-Related Infection.

ABSTRACT: Implant-related infection (IRI) is a major problem in orthopedics. Copper (Cu) is an essential trace element with strong bactericidal activity and, thus, presents potential for reducing IRI. The present study explored a straightforward strategy for releasing Cu²⁺ from titanium (Ti) implants, and we conducted a preliminary study to assess the feasibility of this approach in clinical translation. Polylactic acid (PLA) coatings containing different concentrations of copper ions were prepared on Ti discs. The antibacterial activity and biocompatibility of the copper ion-incorporated Ti implants were evaluated using Staphylococcus aureus (S. aureus), bone marrow mesenchymal stem cells (BMSCs) and animal models. In vitro, the coatings produced burst release of Cu²⁺ i

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9225639 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature