Inflammatory response of gut, spleen, and liver in mice induced by orally administered Porphyromonas gingivalis.

ABSTRACT:

Background

Periodontitis is a chronic multifactorial inflammatory disease. Porphyromonas gingivalis is a primary periopathogen in the initiation and development of periodontal disease. Evidence has shown that P. gingivalis is associated with systemic diseases, including IBD and fatty liver disease. Inflammatory response is a key feature of diseases related to this species.

Methods

C57BL/6 mice were administered either PBS, or P. gingivalis. After 9 weeks, the inflammatory response in gut, spleen, and liver was analyzed.

Results

The findings revealed significant disturbance of the intestinal microbiota and increased inflammatory factors in the gut of P. gingivalis-administered mice. Administrated P. gingivalis remarkably promoted the

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9225697 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature