A causal relationship between childhood obesity and risk of osteoarthritis: results from a two-sample Mendelian randomization analysis.

ABSTRACT:

Purpose

It has been found that childhood obesity (CO) may play an important role in the onset and progression of osteoarthritis (OA). Thus we conducted this mendelian randomisation analysis (MR) to evaluate the causal association between childhood obesity and osteoarthritis.

Methods

Instrumental variables (IVs) were obtained from publicly available genome-wide association study datasets. The leave-one-out sensitivity test, MR Pleiotropy RESidual Sum and Outlier test (MR-PRESSO), and Cochran's Q test were used to confirm the heterogeneity and pleiotropy of identified IVs, then five different models, including the inverse variance weighted model (IVW), weighted median estimator model (WME), weighted model-based method (WM), MR-Egger regression model (MER), and MR-Robust

SUBMITTER: Cao Z 

PROVIDER: S-EPMC9225762 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature