Ameliorating Effect of <i>Malva neglecta</i> Wallr on Obesity and Diabetes in Wistar Rats: A Mechanistic Study.

ABSTRACT: A high caloric food causes deposition of fats that may progress to obesity. Obesity is a risk factor for various metabolic and cardiovascular diseases, including but limited to diabetes mellitus. This study is aimed at determining the ameliorating effect of Malva Neglecta wallr aqueous-methanolic extract (MNME) on obesity and diabetes in Wistar rats. The MNME was chemically characterized by high-performance liquid chromatography (HPLC). The plant extract was evaluated by in vitro α-amylase inhibition and DPPH scavenging activities. Obesity was induced by administering high sugar and fat diet (HSFD) to rats for six weeks, followed by intraperitoneal injection of alloxan monohydrate (150 mg/kg) to induce diabetes. Oral treatments with MNME 250, 500, and 750 mg/kg/day were given

SUBMITTER: Akhtar MF 

PROVIDER: S-EPMC9225868 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature