Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia.

ABSTRACT: Despite recent progress in acute lymphoblastic leukemia (ALL) therapies, a significant subset of adult and pediatric ALL patients has a dismal prognosis. Better understanding of leukemogenesis and recognition of germline genetic changes may provide new tools for treating patients. Given that hematopoietic stem cell transplantation, often from a family member, is a major form of treatment in ALL, acknowledging the possibility of hereditary predisposition is of special importance. Reports of comprehensive germline analyses performed in adult ALL patients are scarce. Aiming at fulfilling this gap of knowledge, we investigated variants in 93 genes predisposing to hematologic malignancies and 70 other cancer-predisposing genes from exome data obtained from 61 adult and 87 pediatric ALL patients

SUBMITTER: Douglas SPM 

PROVIDER: S-EPMC9225984 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature