Ontology highlight
ABSTRACT:
SUBMITTER: Tondini E
PROVIDER: S-EPMC9226002 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Tondini Elena E Reintjens Niels R M NRM Castello Giulia G Arakelian Tsolere T Isendoorn Marjolein M Camps Marcel M Vree Jana J van der Marel Gijs A GA Filippov Dmitri V DV Codee Jeroen D C JDC Ossendorp Ferry F
NPJ vaccines 20220623 1
Adjuvants play a determinant role in cancer vaccination by optimally activating APCs and shaping the T cell response. Bacterial-derived lipid A is one of the most potent immune-stimulators known, and is recognized via Toll-like receptor 4 (TLR4). In this study, we explore the use of the synthetic, non-toxic, lipid A analog CRX-527 as an adjuvant for peptide cancer vaccines. This well-defined adjuvant was covalently conjugated to antigenic peptides as a strategy to improve vaccine efficacy. We sh ...[more]