Integrated multi-omics analyses reveals molecules governing sperm metabolism potentially influence bull fertility.

ABSTRACT: Bull fertility is of paramount importance in bovine industry because semen from a single bull is used to breed several thousands of cows; however, so far, no reliable test is available for bull fertility prediction. In the present study, spermatozoa from high- and low-fertility bulls were subjected to high-throughput transcriptomic, proteomic and metabolomic analysis. Using an integrated multi-omics approach the molecular differences between high- and low-fertility bulls were identified. We identified a total of 18,068 transcripts, 5041 proteins and 3704 metabolites in bull spermatozoa, of which the expression of 4766 transcripts, 785 proteins and 33 metabolites were dysregulated between high- and low-fertility bulls. At transcript level, several genes involved in oxidative phosphorylation

SUBMITTER: Talluri TR 

PROVIDER: S-EPMC9226030 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature