Mnemonic construction and representation of temporal structure in the hippocampal formation.

ABSTRACT: The hippocampal-entorhinal region supports memory for episodic details, such as temporal relations of sequential events, and mnemonic constructions combining experiences for inferential reasoning. However, it is unclear whether hippocampal event memories reflect temporal relations derived from mnemonic constructions, event order, or elapsing time, and whether these sequence representations generalize temporal relations across similar sequences. Here, participants mnemonically constructed times of events from multiple sequences using infrequent cues and their experience of passing time. After learning, event representations in the anterior hippocampus reflected temporal relations based on constructed times. Temporal relations were generalized across sequences, revealing distinct representat

SUBMITTER: Bellmund JLS 

PROVIDER: S-EPMC9226117 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature