Ontology highlight
ABSTRACT:
SUBMITTER: Bullard BL
PROVIDER: S-EPMC9226166 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Bullard Brianna L BL DeBeauchamp Jennifer J Pekarek Matthew J MJ Petro-Turnquist Erika E Vogel Peter P Webby Richard J RJ Weaver Eric A EA
NPJ vaccines 20220623 1
There is a crucial need for an improved H3N2 influenza virus vaccine due to low vaccine efficacy rates and increased morbidity and mortality associated with H3N2-dominated influenza seasons. Here, we utilize a computational design strategy to produce epitope-optimized, broadly cross-reactive H3 hemagglutinins in order to create a universal H3N2 influenza vaccine. The Epigraph immunogens are designed to maximize the viral population frequency of epitopes incorporated into the immunogen. We compar ...[more]