Association between genetic and socioenvironmental risk for schizophrenia during upbringing in a UK longitudinal cohort.

ABSTRACT:

Background

Associations of socioenvironmental features like urbanicity and neighborhood deprivation with psychosis are well-established. An enduring question, however, is whether these associations are causal. Genetic confounding could occur due to downward mobility of individuals at high genetic risk for psychiatric problems into disadvantaged environments.

Methods

We examined correlations of five indices of genetic risk [polygenic risk scores (PRS) for schizophrenia and depression, maternal psychotic symptoms, family psychiatric history, and zygosity-based latent genetic risk] with multiple area-, neighborhood-, and family-level risks during upbringing. Data were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally-representative cohort of 2232 Britis

SUBMITTER: Newbury JB 

PROVIDER: S-EPMC9226384 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature