The Brain in Oral Clefting: A Systematic Review With Meta-Analyses.

ABSTRACT:

Background

Neuroimaging of individuals with non-syndromic oral clefts have revealed subtle brain structural differences compared to matched controls. Previous studies strongly suggest a unified primary dysfunction of normal brain and face development which could explain these neuroanatomical differences and the neuropsychiatric issues frequently observed in these individuals. Currently there are no studies that have assessed the overall empirical evidence of the association between oral clefts and brain structure. Our aim was to summarize the available evidence on potential brain structural differences in individuals with non-syndromic oral clefts and their matched controls.

Methods

MEDLINE, Scopus, Cochrane Central Register of Controlled Trials, Web of Science and Embase we

SUBMITTER: Sandor-Bajusz KA 

PROVIDER: S-EPMC9226441 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature