Associations of Sleep Disorders With Depressive Symptoms in Early and Prodromal Parkinson's Disease.

ABSTRACT:

Background

Non-motor symptoms, including sleep disorders and depression, are common in Parkinson's disease (PD). The purpose of our study is to explore the effect of sleep disorders, including the probable rapid eye movement (REM) sleep behavior disorder (pRBD) and the daytime sleepiness, on depressive symptoms in patients with early and prodromal PD.

Methods

A total of 683 participants who obtained from the Parkinson Progression Markers Initiative (PPMI) were included, consisting of 423 individuals with early PD, 64 individuals with prodromal PD, and 196 healthy controls (HCs), who were followed up to 5 years from baseline. Multiple linear regression models and linear mixed-effects models were conducted to explore the relationship between sleep disorders and depression at b

SUBMITTER: Ma J 

PROVIDER: S-EPMC9226450 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature