Immunologic Biomarkers in Peripheral Blood of Persons With Tuberculosis and Advanced HIV.

ABSTRACT:

Introduction

Tuberculosis (TB) is a common opportunistic infection among people living with HIV. Diagnostic tests such as culture, Xpert-MTB-RIF, and ULTRA have low sensitivity in paucibacillary TB disease; a blood biomarker could improve TB diagnostic capabilities. We assessed soluble factors to identify biomarkers associated with TB among persons with advanced HIV.

Methods

A case-control (1:1) study was conducted, with participants from Rio de Janeiro and Manaus, Brazil. People living with HIV presenting with CD4 count ≤100 cells/mm3 were eligible to participate. Cases had culture-confirmed TB (N=15) (positive for Mycobacterium tuberculosis [Mtb]); controls had HIV-infection only (N=15). Study visits included baseline, month 2 and end of TB therapy, during which sam

SUBMITTER: Queiroz ATL 

PROVIDER: S-EPMC9226490 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature