Sperm-specific protein ACTL7A as a biomarker for fertilization outcomes of assisted reproductive technology.

ABSTRACT: Obtaining high-quality embryos is one of the key factors to improve the clinical pregnancy rate of assisted reproductive technologies (ART). So far, the clinical evaluation of embryo quality depends on embryo morphology. However, the clinical pregnancy rate is still low. Therefore, new indicators are needed to further improve the evaluation of embryo quality. Several studies have shown that the decrease of sperm-specific protein actin-like 7A (ACTL7A) leaded to low fertilization rate, poor embryo development, and even infertility. The aim of this study was to study whether the different expression levels of ACTL7A on sperm can be used as a biomarker for predicting embryo quality. In this study, excluding the factors of severe female infertility, a total of 281 sperm samples were collected

SUBMITTER: Yang TY 

PROVIDER: S-EPMC9226699 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature