Effects of experimental hypovolemia and pain on pre-ejection period and pulse transit time in healthy volunteers.

ABSTRACT: Trauma patients may suffer significant blood loss, and noninvasive methods to diagnose hypovolemia in these patients are needed. Physiologic effects of hypovolemia, aiming to maintain blood pressure, are largely mediated by increased sympathetic nervous activity. Trauma patients may however experience pain, which also increases sympathetic nervous activity, potentially confounding measures of hypovolemia. Elucidating the common and separate effects of the two stimuli on diagnostic methods is therefore important. Lower body negative pressure (LBNP) and cold pressor test (CPT) are experimental models of central hypovolemia and pain, respectively. In the present analysis, we explored the effects of LBNP and CPT on pre-ejection period and pulse transit time, aiming to further elucidate the pot

SUBMITTER: Djupedal H 

PROVIDER: S-EPMC9226798 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature