Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice.

ABSTRACT:

Background

TGFB-induced factor homeobox 2 (TGIF2) has been reported to exert essential functions in brain development. This study aimed to elucidate the correlation of TGIF2 with autism, a neurodevelopmental condition which presents with severe communication problems.

Methods

An autism-related gene expression dataset GSE36315 was used to analyze aberrantly expressed genes in autistic brain tissues. Maternal mice were treated with valproate (VPA), and their offspring were selected as model mice with autism. The functions of TGIF2 in autism-like symptoms in mice were examined by behavioral tests and histological examination of their hippocampal tissues. Mouse hippocampal neurons were extracted for in vitro studies. A gene set enrichment analysis was performed to analyze the si

SUBMITTER: Lei J 

PROVIDER: S-EPMC9226810 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature