Skeletonized mean diffusivity and neuropsychological performance in relapsing-remitting multiple sclerosis.

ABSTRACT:

Background

Peak width of Skeletonized Mean Diffusivity (PSMD), as a novel marker of white matter (WM) microstructure damage, is associated with cognitive decline in several WM pathologies (i.e., small vessel disorders). We hypothesized that markers combining alterations in whole WM could be associated with cognitive dysfunction in relapsing-remitting multiple sclerosis (RRMS) patients.

Methods

We used PSMD based on tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI) magnetic resonance (MR) scans. We investigated RRMS patients (n = 73) undergoing interferon beta (IFN-β) therapy. In this cross-sectional study, we investigated the association between neuropsychological data and clinical and MRI variables: PSMD, WM hypointensities, and normalized brain volume

SUBMITTER: Chylinska M 

PROVIDER: S-EPMC9226842 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature