Associations Between Handgrip Strength and Dementia Risk, Cognition, and Neuroimaging Outcomes in the UK Biobank Cohort Study.

ABSTRACT:

Importance

The associations between muscle strength and cognitive outcomes have sparked interest in interventions that increase muscle strength for prevention of dementia, but the associations between muscle strength and cognitive aging are unclear, particularly among middle-aged adults.

Objective

To evaluate the association between handgrip strength (HGS) and dementia, reduced cognition, and poorer neuroimaging outcomes in a UK population of middle-aged adults.

Design, setting, and participants

This cohort study evaluated UK Biobank participants aged 39 to 73 years enrolled from 2006 to 2010 with measured HGS and prospectively followed up for dementia diagnosis. Data were analyzed from October 2021 to April 2022.

Exposures

HGS assessed in both hands via dynamo

SUBMITTER: Duchowny KA 

PROVIDER: S-EPMC9227006 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature