Low-Energy Electron Induced Reactions in Metronidazole at Different Solvation Conditions.

ABSTRACT: Metronidazole belongs to the class of nitroimidazole molecules and has been considered as a potential radiosensitizer for radiation therapy. During the irradiation of biological tissue, secondary electrons are released that may interact with molecules of the surrounding environment. Here, we present a study of electron attachment to metronidazole that aims to investigate possible reactions in the molecule upon anion formation. Another purpose is to elucidate the effect of microhydration on electron-induced reactions in metronidazole. We use two crossed electron/molecular beam devices with the mass-spectrometric analysis of formed anions. The experiments are supported by quantum chemical calculations on thermodynamic properties such as electron affinities and thresholds of anion formation.

SUBMITTER: Lochmann C 

PROVIDER: S-EPMC9227036 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature