Intervening on the storage time of RBC units and its effects on adverse recipient outcomes using real-world data.

ABSTRACT: Randomized controlled trials (RCTs) have found no evidence that the storage time of transfused red blood cell (RBC) units affects recipient survival. However, inherent difficulties in conducting RBC transfusion RCTs have prompted critique of their design, analyses, and interpretation. Here, we address these issues by emulating hypothetical randomized trials using large real-world data to further clarify the adverse effects of storage time. We estimated the comparative effect of transfusing exclusively older vs fresher RBC units on the primary outcome of death, and the secondary composite end point of thromboembolic events, or death, using inverse probability weighting. Thresholds were defined as 1, 2, 3, and 4 weeks of storage. A large Danish blood transfusion database from the period 2008

SUBMITTER: Bruun-Rasmussen P 

PROVIDER: S-EPMC9227103 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature