High Iron Exposure from the Fetal Stage to Adulthood in Mice Alters Lipid Metabolism.

ABSTRACT: Iron supplementation is recommended during pregnancy and fetal growth. However, excess iron exposure may increase the risk of abnormal fetal development. We investigated the potential side effects of high iron levels in fetuses and through their adult life. C57BL/6J pregnant mice from 2 weeks of gestation and their offspring until 30 weeks were fed a control (CTRL, FeSO₄ 0 g/1 kg) or high iron (HFe, FeSO₄ 9.9 g/1 kg) diets. HFe group showed higher iron accumulation in the liver with increased hepcidin, reduced TfR1/2 mRNAs, and lowered ferritin heavy chain (FTH) proteins in both liver and adipose tissues despite iron loading. HFe decreased body weight, fat weight, adipocyte size, and triglyceride levels in the blood and fat, along with downregulation of lipogenesis ge

SUBMITTER: Kim M 

PROVIDER: S-EPMC9227341 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature