Assessing the Reliability of SARS-CoV-2 Neutralization Studies That Use Post-Vaccination Sera.

ABSTRACT: Assessing COVID-19 vaccine effectiveness against emerging SARS-CoV-2 variants is crucial for determining future vaccination strategies and other public health strategies. When clinical effectiveness data are unavailable, a common method of assessing vaccine performance is to utilize neutralization assays using post-vaccination sera. Neutralization studies are typically performed across a wide array of settings, populations and vaccination strategies, and using different methodologies. For any comparison and meta-analysis to be meaningful, the design and methodology of the studies used must at minimum address aspects that confer a certain degree of reliability and comparability. We identified and characterized three important categories in which studies differ (cohort details, assay details

SUBMITTER: Jacobsen H 

PROVIDER: S-EPMC9227377 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature