Inhaled siRNA Formulations for Respiratory Diseases: From Basic Research to Clinical Application.

ABSTRACT: The development of siRNA technology has provided new opportunities for gene-specific inhibition and knockdown, as well as new ideas for the treatment of disease. Four siRNA drugs have already been approved for marketing. However, the instability of siRNA in vivo makes systemic delivery ineffective. Inhaled siRNA formulations can deliver drugs directly to the lung, showing great potential for treating respiratory diseases. The clinical applications of inhaled siRNA formulations still face challenges because effective delivery of siRNA to the lung requires overcoming the pulmonary and cellular barriers. This paper reviews the research progress for siRNA inhalation formulations for the treatment of various respiratory diseases and summarizes the chemical structural modifications and the vario

SUBMITTER: Fan Y 

PROVIDER: S-EPMC9227582 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature