Development of Sensitization to Multiple Allergen Molecules from Preschool to School Age Is Related to Asthma.

ABSTRACT:

Introduction

Allergic sensitization in early life has been identified as a strong risk factor for subsequent asthma in childhood. It is still unclear why only a part of sensitized children develop asthma, and the role of specific allergen molecules in asthma pathogenesis is ambiguous [Pharmacol Ther. 2009 Feb;121(2):174-84]. We assessed the sensitization to multiple allergen molecules longitudinally and explored its relation to persistent asthma at 7 years.

Methods

Seventy-two children included during an acute wheezing episode (cases) were followed prospectively from early preschool age (EPA) to age 7, and compared to 43 healthy controls at EPA. Allergen molecules were analyzed at EPA and age 7 using ImmunoCAP Solid-phase Allergen Chip (ISAC). Asthma diagnosis at 7 years was

SUBMITTER: Filiou A 

PROVIDER: S-EPMC9227676 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature