Resistance to Erythropoiesis-Stimulating Agents among Patients on Hemodialysis Is Typically Transient.

ABSTRACT:

Introduction

This study examines factors associated with erythropoiesis-stimulating agent (ESA) hyporesponsiveness, the duration of ESA hyporesponsiveness, the frequency of new episodes, and variation across countries.

Methods

We used international Dialysis Outcomes and Practice Patterns Study data from 2015 to 2018 (N = 26,656) to investigate changes in ESA Resistance Index (ERI), calculated as epoetin dose divided by [hemoglobin × body weight] in patients on hemodialysis. We illustrated the proportion of patients who moved to other ERI quintiles over 12 months, and we studied the incidence and duration of ESA resistance. We examined case-mix factors associated with quintiles of ERI.

Results

Most patients migrated out of their original ERI quintile within 4 months. O

SUBMITTER: Goodkin DA 

PROVIDER: S-EPMC9227686 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature