Minute Cellular Nodules as Early Lesions in Rats with Silica Exposure via Inhalation.

ABSTRACT: Mechanisms of silicosis have yet to be clarified, and pathological conditions are inaccurately described in some experimental studies on silicosis. This study was aimed at describing initial lesions in silicosis, as observed in rats with silica exposure via inhalation, and major histopathologic alterations. Male Wistar rats were exposed to silica for 24 weeks. Hematoxylin and eosin staining indicated the presence of "cellular nodule+ macrophage alveolitis" in rats exposed to silica from the 2-16 weeks time points and "fibrotic cellular + cellular nodule" in rats exposed to silica via inhalation for 24 weeks. By immunohistochemistry, the following were noted: a continual increase in the positive expression of CD68 in macrophages in the lungs of rats exposed to silica; hyperplasia in alveola

SUBMITTER: Li Y 

PROVIDER: S-EPMC9227695 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature