An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation.

ABSTRACT: Obesity can lead to chronic inflammation in different tissues, generating insulin and leptin resistance and alterations in glucose and lipid metabolism, favoring the development of degenerative diseases, including type II diabetes. Congruently, the inflammatory signaling inhibition prevents the development of obesity and restores insulin sensitivity. Via the enhancement of central nervous system activity, an enriched environment (EE) has beneficial effects on learning and memory as well as on immune cell functions and inflammation in different disease models. Here, we explored whether an EE can restore energy balance in obese mice that previously presented metabolic alterations. We discovered that an EE improved glucose metabolism, increased insulin signaling in liver, and reduced hepatic

SUBMITTER: Diaz de Leon-Guerrero S 

PROVIDER: S-EPMC9227715 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature