Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC9227816 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Hu Xia X Luo Qian Q Qin Yao Y Wu Yao Y Liu Xue-Wen XW
Molecules (Basel, Switzerland) 20220608 12
With the development of metal-based drugs, Ru(II) compounds present potential applications of PDT (photodynamic therapy) and anticancer reagents. We herein synthesized two naphthyl-appended ruthenium complexes by the combination of the ligand with naphthyl and bipyridyl. The DNA affinities, photocleavage abilities, and photocytotoxicity were studied by various spectral methods, viscosity measurement, theoretical computation method, gel electrophoresis, and MTT method. Two complexes exhibited str ...[more]