Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology.

ABSTRACT: Type 2 diabetes (T2D) is considered one of the largest global public-health concerns, affecting approximately more than 400 million individuals worldwide. The pathogenesis of T2D is very complex and, among the modifiable risk factors, selenium (Se) has recently emerged as a determinant of T2D pathogenesis and progression. Selenium is considered an essential element with antioxidant properties, and is incorporated into the selenoproteins involved in the antioxidant response. Furthermore, deiodinases, the enzymes responsible for homeostasis and for controlling the activity of thyroid hormones (THs), contain Se. Given the crucial action of oxidative stress in the onset of insulin resistance (IR) and T2D, and the close connection between THs and glucose metabolism, Se may be involved in these

SUBMITTER: Gorini F 

PROVIDER: S-EPMC9227825 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature