Pharmacogenetic Analysis of Voriconazole Treatment in Children.

ABSTRACT: Voriconazole is among the first-line antifungal drugs to treat invasive fungal infections in children and known for its pronounced inter- and intraindividual pharmacokinetic variability. Polymorphisms in genes involved in the metabolism and transport of voriconazole are thought to influence serum concentrations and eventually the therapeutic outcome. To investigate the impact of these genetic variants and other covariates on voriconazole trough concentrations, we performed a retrospective data analysis, where we used medication data from 36 children suffering from invasive fungal infections treated with voriconazole. Data were extracted from clinical information systems with the new infrastructure SwissPK^cdw, and linear mixed effects modelling was performed using R. Sampl

SUBMITTER: Tilen R 

PROVIDER: S-EPMC9227859 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature