Phase I Clinical Trial Using [^99mTc]Tc-1-thio-D-glucose for Diagnosis of Lymphoma Patients.

ABSTRACT: Similar to [¹⁸F]-FDG, [^99mTc]Tc-1-thio-D-glucose ([^99mTc]Tc-TG) also binds to GLUT receptors. The aim of this Phase I study was to evaluate the safety, biodistribution and dosimetry of [^99mTc]Tc-TG. Twelve lymphoma patients were injected with 729 ± 102 MBq [^99mTc]Tc-TG. Whole-body planar imaging was performed in 10 patients at 2, 4, 6 and 24 h after injection. In all 12 patients, SPECT/CT (at 2 h) and SPECT (at 4 and 6 h) imaging was performed. Vital signs and possible side effects were monitored during imaging and up to 7 days after injection. [^99mTc]Tc-TG injections were well-tolerated and no side effects or alterations in blood and urine analyses data were observed. The highest absorbed dose was in the kidneys and urinary

SUBMITTER: Chernov V 

PROVIDER: S-EPMC9227866 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature