Simultaneous Spray Drying for Combination Dry Powder Inhaler Formulations.

ABSTRACT: Spray drying is a particle engineering technique used to manufacture respirable pharmaceutical powders that are suitable for delivery to the deep lung. It is amenable to processing both small molecules and biologic actives, including proteins. In this work, a simultaneous spray-drying process, termed simul-spray, is described; the process involves two different active pharmaceutical ingredient (API) solutions that are simultaneously atomized through separate nozzles into a single-spray dryer. Collected by a single cyclone, simul-spray produces a uniform mixture of two different active particles in a single-unit operation. While combination therapies for dry powder inhalers containing milled small molecule API are commercially approved, limited options exist for preparing combination treatm

SUBMITTER: Shepard KB 

PROVIDER: S-EPMC9227944 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature