Proteomic characterization of the human lens and Cataractogenesis.

ABSTRACT:

Introduction

The goal of this review is to highlight the triumphs and frontiers in measurement of the lens proteome as it relates to onset of age-related nuclear cataract. As global life expectancy increases, so too does the frequency of age-related nuclear cataracts. Molecular therapeutics do not exist for delay or relief of cataract onset in humans. Since lens fiber cells are incapable of protein synthesis after initial maturation, age-related changes in proteome composition and post-translational modification accumulation can be measured with various techniques. Several of these modifications have been associated with cataract onset.

Areas covered

We discuss the impact of long-lived proteins on the lens proteome and lens homeostasis as well as proteomic techniques that ma

SUBMITTER: Cantrell LS 

PROVIDER: S-EPMC9227965 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature