Oxytocin and vasotocin receptor variation and the evolution of human prosociality.

ABSTRACT: Modern human lifestyle strongly depends on complex social traits like empathy, tolerance and cooperation. These diverse facets of social cognition have been associated with variation in the oxytocin receptor (OTR) and its sister genes, the vasotocin/vasopressin receptors (VTR1A/AVPR1A and AVPR1B/VTR1B). Here, we compared the available genomic sequences of these receptors between modern humans, archaic humans, and 12 non-human primate species, and identified sites that show heterozygous variation in modern humans and archaic humans distinct from variation in other primates, and for which we could find association studies with clinical implications. On these sites, we performed a range of analyses (variant clustering, pathogenicity prediction, regulation, linkage

SUBMITTER: Theofanopoulou C 

PROVIDER: S-EPMC9227999 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature