Rifampicin-Mediated Metabolic Changes in Mycobacterium tuberculosis.

ABSTRACT: Mycobacterium tuberculosis (Mtb) is considered to be a devastating pathogen worldwide, affecting millions of people globally. Several drugs targeting distinct pathways are utilized for the treatment of tuberculosis. Despite the monumental efforts being directed at the discovery of drugs for Mtb, the pathogen has also developed mechanisms to evade the drug action and host processes. Rifampicin was an early anti-tuberculosis drug, and is still being used as the first line of treatment. This study was carried out in order to characterize the in-depth rifampicin-mediated metabolic changes in Mtb, facilitating a better understanding of the physiological processes based on the metabolic pathways and predicted protein interactors associated with the dysregulated metabolome. A

SUBMITTER: Yelamanchi SD 

PROVIDER: S-EPMC9228056 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature