Enrofloxacin Induces Intestinal Microbiota-Mediated Immunosuppression in Zebrafish.

ABSTRACT: The immunosuppressive effects of antibiotics and the potential associations with the intestinal microbiota of the host have been increasingly recognized in recent years. However, the detailed underlying mechanisms of immune interference of antibiotics in environmental organisms remain unclear, particularly at the early life stage of high sensitivity. To better understand the gut microbiome and immune function interactions, the vertebrate model, zebrafish, was treated with environmentally relevant concentrations of a frequently detected antibiotic, enrofloxacin (ENR), ranging from 0.01 to 100 μg/L. 16S ribosomal RNA sequencing indicated diminished diversity, richness, and evenness of intestinal flora following ENR treatment. Twenty-two taxa of gut bacteria including Rickettsiales,

SUBMITTER: Qiu W 

PROVIDER: S-EPMC9228068 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature