Low-Molecular Pyrazine-Based DNA Binders: Physicochemical and Antimicrobial Properties.

ABSTRACT: Pyrazine and its derivatives are a large group of compounds that exhibit broad biological activity, the changes of which can be easily detected by a substituent effect or a change in the functional group. The present studies combined theoretical research with the density functional theory (DFT) approach (B3LYP/6-311+G**) and experimental (potentiometric and spectrophotometric) analysis for a thorough understanding of the structure of chlorohydrazinopyrazine, its physicochemical and cytotoxic properties, and the site and nature of interaction with DNA. The obtained results indicated that 2-chloro-3-hydrazinopyrazine (2Cl3HP) displayed the highest affinity to DNA. Cytotoxicity studies revealed that the compound did not exhibit toxicity toward human dermal keratinocytes, which supported the p

SUBMITTER: Mech-Warda P 

PROVIDER: S-EPMC9228100 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature