The Effect of Ca²⁺ and Mg²⁺ Ions Loaded at Degradable PLA Membranes on the Proliferation and Osteoinduction of MSCs.

ABSTRACT: Biodegradable membranes, including Polylactic acid (PLA)-based membranes, are commonly used in bone-tissue-related clinical procedures as biointerface to promote bone tissue regeneration. Calcium (Ca²⁺) and Magnesium (Mg²⁺) ions have been related to the promotion of osteogenesis, where the PLA membranes could be used as carrier and delivery substrate for them to provide osteogenic properties to this material. For this aim, a new ion delivery system based on biodegradable PLA membranes loaded with Mg and hydroxyapatite (HA) particles has been processed by the combination of tape casting and colloidal route. Materials characterization shows that the incorporation of Mg and HA particles changes the surface and hydrophobicity of the PLA membrane, and the in vitro degradat

SUBMITTER: Retegi-Carrion S 

PROVIDER: S-EPMC9228138 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature