Going Retro, Going Viral: Experiences and Lessons in Drug Discovery from COVID-19.

ABSTRACT: The severity of the COVID-19 pandemic and the pace of its global spread have motivated researchers to opt for repurposing existing drugs against SARS-CoV-2 rather than discover or develop novel ones. For reasons of speed, throughput, and cost-effectiveness, virtual screening campaigns, relying heavily on in silico docking, have dominated published reports. A particular focus as a drug target has been the principal active site (i.e., RNA synthesis) of RNA-dependent RNA polymerase (RdRp), despite the existence of a second, and also indispensable, active site in the same enzyme. Here we report the results of our experimental interrogation of several small-molecule inhibitors, including natural products proposed to be effective by in silico studies. Notably, we find that two antibiotics in cli

SUBMITTER: Wang B 

PROVIDER: S-EPMC9228142 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature