Metabolomic and Transcriptomic Profiling Identified Significant Genes in Thymic Epithelial Tumor.

ABSTRACT: Thymomas and thymic carcinomas are malignant thymic epithelial tumors (TETs) with poor outcomes if non-resectable. However, the tumorigenesis, especially the metabolic mechanisms involved, is poorly studied. Untargeted metabolomics analysis was utilized to screen for differential metabolic profiles between thymic cancerous tissues and adjunct noncancerous tissues. Combined with transcriptomic data, we comprehensively evaluated the metabolic patterns of TETs. Metabolic scores were constructed to quantify the metabolic patterns of individual tumors. Subsequent investigation of distinct clinical outcomes and the immune landscape associated with the metabolic scores was conducted. Two distinct metabolic patterns and differential metabolic scores were identified between TETs, which were enriche

SUBMITTER: Tang E 

PROVIDER: S-EPMC9228216 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature