Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies.

ABSTRACT: Atopic dermatitis (AD) is a globally prevalent skin inflammation with a particular impact on children. Current therapies for AD are challenged by the limited armamentarium and the high heterogeneity of the disease. A novel promising therapeutic target for AD is the microbiota. Numerous studies have highlighted the involvement of the skin and gut microbiota in the pathogenesis of AD. The resident microbiota at these two epithelial tissues can modulate skin barrier functions and host immune responses, thus regulating AD progression. For example, the pathogenic roles of Staphylococcus aureus in the skin are well-established, making this bacterium an attractive target for AD treatment. Targeting the gut microbiota is another therapeutic strategy for AD. Multiple oral supplements with pr

SUBMITTER: Alam MJ 

PROVIDER: S-EPMC9228373 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature